THE INTRAARTICULATE IMPLANTATION OF BIODEGRADED POLYHYDROXYALKANOATES IN EXPERIMENT

Abstract

The processes of regeneration damaged rat cartilage of knee joint after implantation of biodegraded polyhydroxyalkanoates (PHA) were studied by method of light microscopy. After application PHA the destructive changes in the damaged joints have been expressed much more strongly, than after natural course of healing. In all cases for all terms of supervision the PHA has not been found out between articulate surfaces. However, sometimes PHA lay freely in lateral plicae of articulate capsule. Much more often small fragments of PHA settled in tissues round a joint, were incapsulated by actively proliferated fibrous tissue and were deformed. In all cases there were no reactions of macrophages and leucocytes to a foreign body and signs of granulomatous inflammatory process. There were no also certificates of PHA degradation. The materials, prepared from PHA, are not biodegraded, but are expressed bioinertness.

Keywords

• biodegraded polyhydroxyalkanoates
• knee joint
• damaged cartilage