Real-Time Monitoring of Multistep Batch and Flow Synthesis Processes of a Key Intermediate of Lifitegrast by a Combined Spectrometer System with Both Near-Infrared and Raman Spectroscopies Coupled to Partial Least-Squares
Quan Liu,
Chuanjun Wu,
Huiting Liu,
Mengfei Wang,
Chuanmeng Zhao,
Fuli Zhang
Affiliations
Quan Liu
School of Pharmaceutical Science, Shanghai Jiao Tong University, Shanghai, China
Chuanjun Wu
Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China
Huiting Liu
Shanghai PROXS Chemical Technology Co. Ltd., Shanghai, China
Mengfei Wang
Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China
Chuanmeng Zhao
Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China
Fuli Zhang
Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China
