Disease Models & Mechanisms (Mar 2022)

Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk

  • Lillian Garrett,
  • Patricia Da Silva-Buttkus,
  • Birgit Rathkolb,
  • Raffaele Gerlini,
  • Lore Becker,
  • Adrian Sanz-Moreno,
  • Claudia Seisenberger,
  • Annemarie Zimprich,
  • Antonio Aguilar-Pimentel,
  • Oana V. Amarie,
  • Yi-Li Cho,
  • Markus Kraiger,
  • Nadine Spielmann,
  • Julia Calzada-Wack,
  • Susan Marschall,
  • Dirk Busch,
  • Carsten Schmitt-Weber,
  • Eckhard Wolf,
  • Wolfgang Wurst,
  • Helmut Fuchs,
  • Valerie Gailus-Durner,
  • Sabine M. Hölter,
  • Martin Hrabě de Angelis

DOI
https://doi.org/10.1242/dmm.049205
Journal volume & issue
Vol. 15, no. 3

Abstract

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Understanding the shared genetic aetiology of psychiatric and medical comorbidity in neurodevelopmental disorders (NDDs) could improve patient diagnosis, stratification and treatment options. Rare tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (TANC2)-disrupting variants were disease causing in NDD patients. The post-synaptic scaffold protein TANC2 is essential for dendrite formation in synaptic plasticity and plays an unclarified but critical role in development. We here report a novel homozygous-viable Tanc2-disrupted function model in which mutant mice were hyperactive and had impaired sensorimotor gating consistent with NDD patient psychiatric endophenotypes. Yet, a multi-systemic analysis revealed the pleiotropic effects of Tanc2 outside the brain, such as growth failure and hepatocellular damage. This was associated with aberrant liver function including altered hepatocellular metabolism. Integrative analysis indicates that these disrupted Tanc2 systemic effects relate to interaction with Hippo developmental signalling pathway proteins and will increase the risk for comorbid somatic disease. This highlights how NDD gene pleiotropy can augment medical comorbidity susceptibility, underscoring the benefit of holistic NDD patient diagnosis and treatment for which large-scale preclinical functional genomics can provide complementary pleiotropic gene function information.

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