Cancers (Feb 2021)
Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients
- Filippo Pelizzaro,
- Alessandro Vitale,
- Anna Sartori,
- Andrea Vieno,
- Barbara Penzo,
- Francesco Paolo Russo,
- Anna Chiara Frigo,
- Edoardo G Giannini,
- Manuela Piccinnu,
- Gian Ludovico Rapaccini,
- Maria Di Marco,
- Eugenio Caturelli,
- Marco Zoli,
- Rodolfo Sacco,
- Ciro Celsa,
- Fabio Marra,
- Andrea Mega,
- Maria Guarino,
- Antonio Gasbarrini,
- Gianluca Svegliati-Baroni,
- Francesco Giuseppe Foschi,
- Andrea Olivani,
- Alberto Masotto,
- Pietro Coccoli,
- Giovanni Raimondo,
- Francesco Azzaroli,
- Gianpaolo Vidili,
- Maurizia Rossana Brunetto,
- Franco Trevisani,
- Fabio Farinati,
- on behalf of ITA.LI.CA Study Group
Affiliations
- Filippo Pelizzaro
- Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
- Alessandro Vitale
- Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
- Anna Sartori
- Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
- Andrea Vieno
- Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
- Barbara Penzo
- Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
- Francesco Paolo Russo
- Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
- Anna Chiara Frigo
- Biostatistics Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy
- Edoardo G Giannini
- Gastroenterology Unit, Department of Internal Medicine, University of Genova, IRCCS Policlinico San Martino, 16132 Genova, Italy
- Manuela Piccinnu
- Internal Medicine–Piscaglia Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, Italy
- Gian Ludovico Rapaccini
- Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, Italy
- Maria Di Marco
- Medicine Unit, Bolognini Hospital, 24068 Seriate, Italy
- Eugenio Caturelli
- Gastroenterology Unit, Belcolle Hospital, 01100 Viterbo, Italy
- Marco Zoli
- Internal Medicine–Zoli Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, Italy
- Rodolfo Sacco
- Gastroenterology and Digestive Endoscopy Unit, Foggia University Hospital, 71122 Foggia, Italy
- Ciro Celsa
- Gastroenterology & Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, PROMISE, University of Palermo, 90133 Palermo, Italy
- Fabio Marra
- Internal Medicine and Hepatology Unit, Department of Experimental and Clinical Medicine, University of Firenze, 50121 Firenze, Italy
- Andrea Mega
- Gastroenterology Unit, Bolzano Regional Hospital, 39100 Bolzano, Italy
- Maria Guarino
- Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Napoli “Federico II”, 80138 Napoli, Italy
- Antonio Gasbarrini
- Internal Medicine and Gastroenterology Unit, Policlinico Gemelli, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
- Gianluca Svegliati-Baroni
- Gastroenterology Unit, Polytechnic University of Marche, 60121 Ancona, Italy
- Francesco Giuseppe Foschi
- Department of Internal Medicine, Ospedale per gli Infermi di Faenza, 48018 Faenza, Italy
- Andrea Olivani
- Infectious Diseases and Hepatology Unit, Azienda Ospedaliero-Universitaria di Parma, 43126 Parma, Italy
- Alberto Masotto
- Gastroenterology Unit, Ospedale Sacro Cuore Don Calabria, 37024 Negrar, Italy
- Pietro Coccoli
- Hepato-Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Napoli “Federico II”, 80138 Napoli, Italy
- Giovanni Raimondo
- Clinical and Molecular Hepatology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy
- Francesco Azzaroli
- Gastroenterology Unit, Department of Surgical and Medical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, Italy
- Gianpaolo Vidili
- Clinica Medica Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Azienda Ospedaliero-Universitaria di Sassari, 07100 Sassari, Italy
- Maurizia Rossana Brunetto
- Department of Clinical and Experimental Medicine, Hepatology and Liver Physiopathology Laboratory and Internal Medicine, University of Pisa, 56126 Pisa, Italy
- Franco Trevisani
- Medical Semeiotics Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
- Fabio Farinati
- Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
- on behalf of ITA.LI.CA Study Group
- DOI
- https://doi.org/10.3390/cancers13040897
- Journal volume & issue
-
Vol. 13,
no. 4
p. 897
Abstract
Purpose: We aimed at assessing the impact of surveillance on long-term survival in HCC patients. Methods: From the ITA.LI.CA database, we selected 1028 cases with long (≥5 years, LS group) and 2721 controls with short-term survival (p p p p = 0.0008, respectively). In IPW adjusted populations, no survival differences were demonstrated between the two groups (p = 0.30). Conclusions: Surveillance, increasing early-stage diagnosis and applicability of curative treatments, is a fundamental determinant of long-term survival in HCC patients. A wide implementation of surveillance programs should be pursued in order to improve HCC patients’ prognosis.
Keywords
