Nature Communications (Aug 2021)

Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

  • Henning Jacobsen,
  • Kerstin Walendy-Gnirß,
  • Nilgün Tekin-Bubenheim,
  • Nancy Mounogou Kouassi,
  • Isabel Ben-Batalla,
  • Nikolaus Berenbrok,
  • Martin Wolff,
  • Vinicius Pinho dos Reis,
  • Martin Zickler,
  • Lucas Scholl,
  • Annette Gries,
  • Hanna Jania,
  • Andreas Kloetgen,
  • Arne Düsedau,
  • Gundula Pilnitz-Stolze,
  • Aicha Jeridi,
  • Ali Önder Yildirim,
  • Helmut Fuchs,
  • Valerie Gailus-Durner,
  • Claudia Stoeger,
  • Martin Hrabe de Angelis,
  • Tatjana Manuylova,
  • Karin Klingel,
  • Fiona J. Culley,
  • Jochen Behrends,
  • Sonja Loges,
  • Bianca Schneider,
  • Susanne Krauss-Etschmann,
  • Peter Openshaw,
  • Gülsah Gabriel

DOI
https://doi.org/10.1038/s41467-021-25220-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Influenza infection during pregnancy can affect health of offspring but it is not clear how this affects immune responses. Here the authors use a mouse model to show that influenza infection during pregnancy can increase susceptibility to secondary infection and alter immune cell function in offspring.