Nature Communications (Aug 2021)
Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life
- Henning Jacobsen,
- Kerstin Walendy-Gnirß,
- Nilgün Tekin-Bubenheim,
- Nancy Mounogou Kouassi,
- Isabel Ben-Batalla,
- Nikolaus Berenbrok,
- Martin Wolff,
- Vinicius Pinho dos Reis,
- Martin Zickler,
- Lucas Scholl,
- Annette Gries,
- Hanna Jania,
- Andreas Kloetgen,
- Arne Düsedau,
- Gundula Pilnitz-Stolze,
- Aicha Jeridi,
- Ali Önder Yildirim,
- Helmut Fuchs,
- Valerie Gailus-Durner,
- Claudia Stoeger,
- Martin Hrabe de Angelis,
- Tatjana Manuylova,
- Karin Klingel,
- Fiona J. Culley,
- Jochen Behrends,
- Sonja Loges,
- Bianca Schneider,
- Susanne Krauss-Etschmann,
- Peter Openshaw,
- Gülsah Gabriel
Affiliations
- Henning Jacobsen
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Kerstin Walendy-Gnirß
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Nilgün Tekin-Bubenheim
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Nancy Mounogou Kouassi
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Isabel Ben-Batalla
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Nikolaus Berenbrok
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Martin Wolff
- Early Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Member of the German Center for Lung Research (DZL)
- Vinicius Pinho dos Reis
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Martin Zickler
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Lucas Scholl
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Annette Gries
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Hanna Jania
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- Andreas Kloetgen
- Department of Computational Biology of Infection Research, Helmholtz Centre for Infection Research
- Arne Düsedau
- Flow Cytometry/FACS Unit, Leibniz-Institute for Experimental Virology
- Gundula Pilnitz-Stolze
- Microscopy and Image Analysis Unit, Leibniz-Institute for Experimental Virology
- Aicha Jeridi
- Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Center Munich, German Research Center for Environmental Health
- Ali Önder Yildirim
- Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Center Munich, German Research Center for Environmental Health
- Helmut Fuchs
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health
- Valerie Gailus-Durner
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health
- Claudia Stoeger
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health
- Martin Hrabe de Angelis
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health
- Tatjana Manuylova
- Institute for Pathology and Neuropathology, University Hospital Tübingen
- Karin Klingel
- Institute for Pathology and Neuropathology, University Hospital Tübingen
- Fiona J. Culley
- National Heart and Lung Institute, Imperial College London
- Jochen Behrends
- Core Facility Fluorescence Cytometry, Research Center Borstel, Leibniz Lung Center
- Sonja Loges
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Bianca Schneider
- Junior Research Group Coinfection, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center
- Susanne Krauss-Etschmann
- Early Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Member of the German Center for Lung Research (DZL)
- Peter Openshaw
- National Heart and Lung Institute, Imperial College London
- Gülsah Gabriel
- Department of Viral Zoonoses – One Health, Leibniz Institute for Experimental Virology
- DOI
- https://doi.org/10.1038/s41467-021-25220-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Influenza infection during pregnancy can affect health of offspring but it is not clear how this affects immune responses. Here the authors use a mouse model to show that influenza infection during pregnancy can increase susceptibility to secondary infection and alter immune cell function in offspring.
