Metabolic markers of early diagnostics of atrophic colpitis

Abstract

35 women (middle age 51±2.8 years) with slight atrophy of vaginal tissue confirmed by hystomorphologic analysis were investigated. Pathogeneticaly important metabolic criteria of tissues and peripheral blood erythrocytes sensitive to hypoxia were chosen in the purpose of improve efficacy of early diagnostics of atrophic colpitis. Concentration of 2.3-BPG, lactate and pyruvate was higher in erythrocytes of all women in clinical group in relation to group of compare. Inhibition of respiratory chain enzymes activity: succinatedehydrogenase and cytochromeoxydase was registered in vaginal tissue of women in clinical group taking intra operationally. Our results testify about changes in metabolism of tissue and erythrocytes that can be early markers of atrophy formation. The results of our investigation gave us the possibility to create the new method of hypoxia diagnostic as predictor of tissue atrophic changes.

Keywords

• атрофический кольпит
• гипоксия
• метаболизм
• atrophic colpitis
• hypoxia
• metabolism