DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

Zengli Guo; Qing Kong; Cui Liu; Song Zhang; Liyun Zou; Feng Yan; Jason K. Whitmire; Yue Xiong; Xian Chen; Yisong Y. Wan

doi:10.1038/ncomms10307

Nature Communications (Jan 2016)

DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

Zengli Guo,
Qing Kong,
Cui Liu,
Song Zhang,
Liyun Zou,
Feng Yan,
Jason K. Whitmire,
Yue Xiong,
Xian Chen,
Yisong Y. Wan

Affiliations

Zengli Guo: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Qing Kong: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Cui Liu: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Song Zhang: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Liyun Zou: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Feng Yan: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Jason K. Whitmire: Department of Genetics, University of North Carolina at Chapel Hill
Yue Xiong: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Xian Chen: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Yisong Y. Wan: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/ncomms10307
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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DCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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