T cells specific for post-translational modifications escape intrathymic tolerance induction

Bruno Raposo; Patrick Merky; Christina Lundqvist; Hisakata Yamada; Vilma Urbonaviciute; Colin Niaudet; Johan Viljanen; Jan Kihlberg; Bruno Kyewski; Olov Ekwall; Rikard Holmdahl; Johan Bäcklund

doi:10.1038/s41467-017-02763-y

Nature Communications (Jan 2018)

T cells specific for post-translational modifications escape intrathymic tolerance induction

Bruno Raposo,
Patrick Merky,
Christina Lundqvist,
Hisakata Yamada,
Vilma Urbonaviciute,
Colin Niaudet,
Johan Viljanen,
Jan Kihlberg,
Bruno Kyewski,
Olov Ekwall,
Rikard Holmdahl,
Johan Bäcklund

Affiliations

Bruno Raposo: Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Patrick Merky: Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Christina Lundqvist: Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg
Hisakata Yamada: Division of Host Defense, Medical Institute of Bioregulation, Kyushu University
Vilma Urbonaviciute: Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Colin Niaudet: Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Johan Viljanen: Department of Chemistry, BMC Uppsala University
Jan Kihlberg: Department of Chemistry, BMC Uppsala University
Bruno Kyewski: Division of Developmental Immunology Tumor Immunology Program, German Cancer Research Center (DKFZ)
Olov Ekwall: Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg
Rikard Holmdahl: Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Johan Bäcklund: Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet

DOI: https://doi.org/10.1038/s41467-017-02763-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed. Here, the authors show that T cells specific for post-translational modifications of type II collagen escape intrathymic tolerance induction in a mouse model of rheumatoid arthritis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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