Nature Communications (May 2016)

Iso-acoustic focusing of cells for size-insensitive acousto-mechanical phenotyping

  • Per Augustsson,
  • Jonas T. Karlsen,
  • Hao-Wei Su,
  • Henrik Bruus,
  • Joel Voldman

DOI
https://doi.org/10.1038/ncomms11556
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Acoustophoresis, a method to manipulate individual cells based on their acoustic properties is confounded by a strong dependency on cell size. Here the authors present iso-acoustic focussing, a way to separate cells in a microfluidic chamber according to their effective acoustic impedance, independent of their size.