Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling

Yue Li; Pengzhen Dong; Yang Yang; Tianyu Guo; Quanyi Zhao; Dan Miao; Huanle Li; Tianfeng Lu; Fanning Xia; Jialan Lyu; Jun Ma; Thomas B. Kornberg; Qiang Zhang; Hai Huang

doi:10.1038/s41467-022-30492-4

Nature Communications (May 2022)

Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling

Yue Li,
Pengzhen Dong,
Yang Yang,
Tianyu Guo,
Quanyi Zhao,
Dan Miao,
Huanle Li,
Tianfeng Lu,
Fanning Xia,
Jialan Lyu,
Jun Ma,
Thomas B. Kornberg,
Qiang Zhang,
Hai Huang

Affiliations

Yue Li: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Pengzhen Dong: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Yang Yang: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Tianyu Guo: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Quanyi Zhao: National Center for Cardiovascular Disease, Fuwai Hospital
Dan Miao: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Huanle Li: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Tianfeng Lu: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Fanning Xia: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Jialan Lyu: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Jun Ma: Zhejiang Provincial Key Laboratory of Genetic & Developmental Disorders, Zhejiang University School of Medicine
Thomas B. Kornberg: Cardiovascular Research Institute, University of California San Francisco
Qiang Zhang: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine
Hai Huang: Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-30492-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Tracheal remodeling is a key step during Drosophila metamorphosis. Here they report that tracheal progenitor cells are activated through Yorkie-dependent proliferation and migration, which is induced by metabolic deficit and insulin signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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