Nature Communications (Mar 2021)
N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
- Weinan Qiu,
- Qingyang Zhang,
- Rui Zhang,
- Yangxu Lu,
- Xin Wang,
- Huabin Tian,
- Ying Yang,
- Zijuan Gu,
- Yanan Gao,
- Xin Yang,
- Guanshen Cui,
- Baofa Sun,
- Yanan Peng,
- Hongyu Deng,
- Hua Peng,
- Angang Yang,
- Yun-Gui Yang,
- Pengyuan Yang
Affiliations
- Weinan Qiu
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Qingyang Zhang
- Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, China National Center for Bioinformation, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Rui Zhang
- The State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University
- Yangxu Lu
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Xin Wang
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Huabin Tian
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Ying Yang
- Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, China National Center for Bioinformation, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Zijuan Gu
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Yanan Gao
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Xin Yang
- Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, China National Center for Bioinformation, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Guanshen Cui
- Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, China National Center for Bioinformation, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Baofa Sun
- Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, China National Center for Bioinformation, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Yanan Peng
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Hongyu Deng
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Hua Peng
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Angang Yang
- The State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University
- Yun-Gui Yang
- Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, China National Center for Bioinformation, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Pengyuan Yang
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-021-21904-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
N6-methyladenosine (m6A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m6A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m6A modification, decreases viral ds RNA content, and thereby dampens the RIG/MDA5-induced anti-viral immunity.
