Serological markers of hepatitis B in Students at Babol University of Medical Sciences

Abstract

Background: Nearly 350 million people worldwide are carriers of the Hepatitis B virus (HBV). A medical worker is one of the most important occupational groups at risk for the virus. Despite vaccination, in many of them, antibody reduced and if the exposure to infected materials, there is a possibility of infection to HBV. This study, examines some of hepatitis B serologic markers among students in Babol University of Medical Sciences. Materials and Methods: 236 students in Babol University of Medical Sciences were enrolled to our study. For all students participating in the study, a questionnaire including demographic information, history of the first and last dose vaccination for Hepatitis B, blood transfusion and blood products and surgical history were completed. 5 ml of venous blood was taken from each student and serum was separated and stored in -20 oC. For all samples, ELISA test operated for Anti-HBs and Anti-HBc and HBsAg. Results: Of the 236 students, 155 (65.7%) were female and 81 (34.3%) were males; of which 194 cases (82.2%) completed the vaccination period, 22 (9.3%) incomplete vaccination or Not vaccinated and others students (8.5%) were unaware of their vaccination status. The presence of Anti-HBs, 202 cases (85.6%) were positive and 34 (14.4%) were negative and Anti-HBc were positive in 4 students (1.7%). Also, all samples were negative by the presence of HBsAg. Conclusion: About 15% of students are susceptible to HBV; therefore, screening for antibody to be recommended, before enter to university. Serological studies in preclinical years are necessary to ensure adequate protection before the students are in close contacts to patients.

Keywords

• hepatitis B
• serologic markers
• vaccinations
• medical students.