Granulosis rubra nasi: a rare condition treated successfully with topical tacrolimus

Abstract

A 20 years-old girl presented with multiple asymptomatic reddish vesicles on face for four years. It used to get worse in summer and was associated with localized hyperhidrosis. The lesions were notable for disappearance on diascopy. Histopathology from the vesicle showed mononuclear cell infiltration in the upper dermis, especially around eccrine sweat apparatus, along with dilatation of superficial capillaries and lymphatics. Based on clinical presentation and histopathology, diagnosis of Granulosis rubra nasi (GRN) was made. GRN usually resolves at puberty; however, rarely it may persist in adulthood. We here report a case of GRN having lesions in adulthood. Moreover, she showed excellent response to topical tacrolimus, a finding not observed in literature.

Keywords

• Granulosis rubra nasi, GRN, eccrine sweat glands, face, hyperhidrosis