mSphere of Influence: a Systematic Approach To Dissect Virulence Traits in <named-content content-type="genus-species">Candida albicans</named-content>

Abstract

ABSTRACT J. Christian Pérez studies the interplay between Candida albicans and the mammalian host. In this mSphere of Influence article, he reflects on how “Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity” (S. M. Noble, S. French, L. A. Kohn, V. Chen, et al., Nat Genet 42:590–598, 2010, https://doi.org/10.1038/ng.605) provided tools and a blueprint for open-ended genetic screens in an organism that had been a challenge for genetic manipulation.

Keywords

• Candida albicans