Nature Communications (Aug 2019)
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis
- Stephan C. Collins,
- Anna Mikhaleva,
- Katarina Vrcelj,
- Valerie E. Vancollie,
- Christel Wagner,
- Nestor Demeure,
- Helen Whitley,
- Meghna Kannan,
- Rebecca Balz,
- Lauren F. E. Anthony,
- Andrew Edwards,
- Hervé Moine,
- Jacqueline K. White,
- David J. Adams,
- Alexandre Reymond,
- Christopher J. Lelliott,
- Caleb Webber,
- Binnaz Yalcin
Affiliations
- Stephan C. Collins
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- Anna Mikhaleva
- Center for Integrative Genomics, University of Lausanne
- Katarina Vrcelj
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Valerie E. Vancollie
- Wellcome Sanger Institute
- Christel Wagner
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- Nestor Demeure
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- Helen Whitley
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- Meghna Kannan
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- Rebecca Balz
- Center for Integrative Genomics, University of Lausanne
- Lauren F. E. Anthony
- Wellcome Sanger Institute
- Andrew Edwards
- Woodland View Hospital, NHS Ayrshire and Arran
- Hervé Moine
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- Jacqueline K. White
- Wellcome Sanger Institute
- David J. Adams
- Wellcome Sanger Institute
- Alexandre Reymond
- Center for Integrative Genomics, University of Lausanne
- Christopher J. Lelliott
- Wellcome Sanger Institute
- Caleb Webber
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Binnaz Yalcin
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- DOI
- https://doi.org/10.1038/s41467-019-11431-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here, authors analyzed 118 neuroanatomical parameters in 1,566 mutant mouse lines to identify 198 genes whose disruptions yield neuroanatomical phenotypes
