Clinical, Cosmetic and Investigational Dermatology (Sep 2021)
The Picosecond Laser Effects on Tattoo Removal and Metabolic Pathways
Abstract
Yan Qu,1 Xien Feng,2 Jin’ning Liang,2 Junru Liu,3 Dong Gao2 1Department of Dermatology, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong, 261031, People’s Republic of China; 2Department of Dermatology, Yantai Yuhuangding Hospital, Yantai, 264003, Shandong, People’s Republic of China; 3Department of Dermatology, Yantai Yuhuangding Hospital Laishan Branch, Yantai, 264003, Shandong, People’s Republic of ChinaCorrespondence: Dong Gao Email [email protected]: We aimed to investigate picosecond laser effects regarding rat tattoo removals. We systematically detected the metabolic pathways considering tattoo pigment particles in rat models.Materials and Methods: We employed fluorescein to mark the tattoo dye and utilized a pattern needle to prepare tattoo on rat so as to establish the tattoo removal effects of picosecond laser methods employing animal models. We applied a picosecond laser to process the tattoo and observed the effects along with metabolic pathways for tattoo removal via pathology and imaging approaches.Results: Based on the results of characterization, pathology and fluorescence, we discovered that the picosecond laser could effectively remove the pigment particles on rat skin, part of which would be metabolized out of the body through the circulatory system. After picosecond laser treatment, the fluorescence intensity of the rat skin engraved part was gradually weakened. At 8 h after the treatment, the metabolic organs had weak fluorescence, and there was no fluorescence in the metabolic organs at 12 h and 24 h after the treatment.Conclusion: The picosecond laser had perfect tattoo removal effects, which could be utilized as a reference for clinical tattoo removal.Keywords: tattoo, picosecond laser, pattern engraving, dye
