Nature Communications (Jun 2018)
Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation
- Tali Lang,
- Jacinta P. W. Lee,
- Kirstin Elgass,
- Anita A. Pinar,
- Michelle D. Tate,
- Elizabeth H. Aitken,
- Huapeng Fan,
- Sarah J. Creed,
- Nadia S. Deen,
- Daouda A. K. Traore,
- Ivo Mueller,
- Danielle Stanisic,
- Francesca S. Baiwog,
- Colin Skene,
- Matthew C. J. Wilce,
- Ashley Mansell,
- Eric F. Morand,
- James Harris
Affiliations
- Tali Lang
- Rheumatology Research Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing & Health Sciences, Monash University
- Jacinta P. W. Lee
- Rheumatology Research Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing & Health Sciences, Monash University
- Kirstin Elgass
- Monash Micro Imaging, Hudson Institute of Medical Research
- Anita A. Pinar
- Rheumatology Research Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing & Health Sciences, Monash University
- Michelle D. Tate
- Centre for Innate Immunity and Infectious Disease, Hudson Institute of Medical Research
- Elizabeth H. Aitken
- Department of Medicine, Peter Doherty Institute, University of Melbourne
- Huapeng Fan
- Rheumatology Research Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing & Health Sciences, Monash University
- Sarah J. Creed
- Monash Micro Imaging, Hudson Institute of Medical Research
- Nadia S. Deen
- Rheumatology Research Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing & Health Sciences, Monash University
- Daouda A. K. Traore
- Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Ivo Mueller
- Population Health and Immunity Division, Walter and Eliza Hall Institute, Parkville
- Danielle Stanisic
- Infection and Immunity Division, Walter and Eliza Hall, Institute of Medical Research
- Francesca S. Baiwog
- Papua New Guinea Institute of Medical Research
- Colin Skene
- Department of Chemistry, University of Melbourne
- Matthew C. J. Wilce
- Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Ashley Mansell
- Centre for Innate Immunity and Infectious Disease, Hudson Institute of Medical Research
- Eric F. Morand
- Rheumatology Research Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing & Health Sciences, Monash University
- James Harris
- Rheumatology Research Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing & Health Sciences, Monash University
- DOI
- https://doi.org/10.1038/s41467-018-04581-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
MIF is a cytokine best known for its modulatory effect on expression of proinflammatory cytokines. Here the authors show that MIF facilitates the NLRP3–vimentin interaction, resulting in Nlrp3 inflammasome activation.
