Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay

Sophie Martin; Kevin C. Allan; Otis Pinkard; Thomas Sweet; Paul J. Tesar; Jeff Coller

doi:10.1038/s41467-022-32766-3

Nature Communications (Aug 2022)

Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay

Sophie Martin,
Kevin C. Allan,
Otis Pinkard,
Thomas Sweet,
Paul J. Tesar,
Jeff Coller

Affiliations

Sophie Martin: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine
Kevin C. Allan: Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
Otis Pinkard: Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
Thomas Sweet: Center for Proteomics and Bioinformatics, Department of Nutrition, Case Western Reserve University School of Medicine
Paul J. Tesar: Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
Jeff Coller: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-32766-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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Mutations in tRNA processing factors can lead to myelin disorders. This study shows that differentiated oligodendrocytes, cells that make the myelin, are characterized by different tRNA modifications and mRNA decay compared to their precursor cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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