Molecules (Jan 2015)

Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)

  • Giuseppina Autore,
  • Stefania Marzocco,
  • Carmen Formisano,
  • Maurizio Bruno,
  • Sergio Rosselli,
  • Mariem Ben Jemia,
  • Felice Senatore

DOI
https://doi.org/10.3390/molecules20011571
Journal volume & issue
Vol. 20, no. 1
pp. 1571 – 1578

Abstract

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The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.

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