Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site

• Felix Wiedmann,
• Aytug K. Kiper,
• Mauricio Bedoya,
• Antonius Ratte,
• Susanne Rinné,
• Manuel Kraft,
• Maximilian Waibel,
• Priya Anad,
• Wolfgang Wenzel,
• Wendy González,
• Hugo A. Katus,
• Niels Decher,
• Constanze Schmidt

Affiliations

Felix Wiedmann

Department of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Heidelberg /Mannheim, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany

Aytug K. Kiper

Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany

Mauricio Bedoya

Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile

Antonius Ratte

Department of Cardiology, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany

Susanne Rinné

Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany

Manuel Kraft

Department of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Heidelberg /Mannheim, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany

Maximilian Waibel

Department of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Heidelberg /Mannheim, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany

Priya Anad

Institute of Nanotechnology, Karlsruhe Institute of Technology, Karlsruhe, Germany

Wolfgang Wenzel

Institute of Nanotechnology, Karlsruhe Institute of Technology, Karlsruhe, Germany

Wendy González

Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, Talca, Chile

Hugo A. Katus

Department of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Heidelberg /Mannheim, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany

Niels Decher

Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany

Constanze Schmidt

Department of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Heidelberg /Mannheim, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany