OncoTargets and Therapy (Aug 2021)
Prognostic Value of miR-1826 in Prostate Cancer and Its Regulatory Effect on Tumor Progression
Abstract
Yongguo Liu,1 Jing Liu,2 Xiancheng Han,1 Linkai Mou1 1Department of Urology, Affiliated Hospital of Weifang Medical University, Weifang, 261031, Shandong, People’s Republic of China; 2Department of Pathology, Weifang Traditional Chinese Hospital, Weifang, 261041, Shandong, People’s Republic of ChinaCorrespondence: Xiancheng HanDepartment of Urology, Affiliated Hospital of Weifang Medical University, No. 2428, Yuhe Road, Weifang, 261031, Shandong, People’s Republic of ChinaTel +86 536 3081339Email [email protected]: miRNAs can act as oncogenes or tumor suppressors and participate in the development and progression of tumors, thus affecting the prognosis and survival of cancer patients. In this paper, we mainly studied the role of miR-1826 in prostate cancer.Patients and Methods: The expression of miR-1826 was studied by quantitative real-time PCR (qRT-PCR). Kaplan–Meier curves were used to analyze the relationship between the expression of miR-1826 and the survival rate of PC patients. Cox regression analysis was used to study the risk factors affecting the prognosis of PC patients. PC cells were transfected with miR-1826 mimic, mimic negative control (mimic NC), miR-1826 inhibitor, or inhibitor NC. The effect of miR-1826 on the proliferation of PC cells was studied by the CCK-8 method and colony formation assay. Transwell assays were used to detect the effect of miR-1826 on the migratory and invasive abilities of tumor cells.Results: The expression of miR-1826 in PC tissues was lower than that in adjacent normal tissues, and that the expression levels of miR-1826 in four PC cell lines were all lower than normal human prostate epithelial cell lines. Patients with low expression of miR-1826 had shorter overall survival compared with those with high expression. The downregulation of miR-1826 promoted PC cell proliferation, migration, and invasion.Conclusion: In summary, the low expression of miR-1826 may promote the progression of PC, and the low expression of miR-1826 is also associated with a poor prognosis in PC patients.Keywords: miR-1826, prostate cancer, prognostic value, progression, treatment
