Frontiers in Endocrinology (Mar 2024)
Is the leptin/BMI ratio a reliable biomarker for endometriosis?
- Aleksandra Zyguła,
- Anna Sankiewicz,
- Agata Sakowicz,
- Ewa Dobrzyńska,
- Agnieszka Dakowicz,
- Grzegorz Mańka,
- Mariusz Kiecka,
- Robert Spaczynski,
- Robert Spaczynski,
- Piotr Piekarski,
- Beata Banaszewska,
- Artur Jakimiuk,
- Artur Jakimiuk,
- Tadeusz Issat,
- Wojciech Rokita,
- Wojciech Rokita,
- Jakub Młodawski,
- Jakub Młodawski,
- Maria Szubert,
- Maria Szubert,
- Piotr Sieroszewski,
- Piotr Sieroszewski,
- Grzegorz Raba,
- Grzegorz Raba,
- Kamil Szczupak,
- Kamil Szczupak,
- Tomasz Kluza,
- Marek Kluza,
- Piotr Pierzyński,
- Cezary Wojtyla,
- Cezary Wojtyla,
- Michal Lipa,
- Damian Warzecha,
- Damian Warzecha,
- Damian Warzecha,
- Miroslaw Wielgos,
- Miroslaw Wielgos,
- Miroslaw Wielgos,
- Krzysztof Cendrowski,
- Ewa Gorodkiewicz,
- Piotr Laudanski,
- Piotr Laudanski,
- Piotr Laudanski
Affiliations
- Aleksandra Zyguła
- OVIklinika Infertility Center, Warsaw, Poland
- Anna Sankiewicz
- Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, Bialystok, Poland
- Agata Sakowicz
- Department of Medical Biotechnology, Medical University of Lodz, Lodz, Poland
- Ewa Dobrzyńska
- Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Warsaw, Poland
- Agnieszka Dakowicz
- Department of Rehabilitation, Medical University of Bialystok, Bialystok, Poland
- Grzegorz Mańka
- Angelius Provita Hospital, Katowice, Poland
- Mariusz Kiecka
- Angelius Provita Hospital, Katowice, Poland
- Robert Spaczynski
- Center for Gynecology, Obstetrics and Infertility Treatment Pastelova, Poznan, Poland
- Robert Spaczynski
- Collegium Medicum, University of Zielona Gora, Zielona Gora, Poland
- Piotr Piekarski
- Gynecological Obstetric Clinical Hospital of Poznan University of Medical Sciences, Minimally Invasive Gynecological Surgery, Poznan, Poland
- Beata Banaszewska
- 0Chair and Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland
- Artur Jakimiuk
- 1Department of Reproductive Health, Institute of Mother and Child in Warsaw, Warsaw, Poland
- Artur Jakimiuk
- 2Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland
- Tadeusz Issat
- 3Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Warsaw, Poland
- Wojciech Rokita
- 4Collegium Medicum, Jan Kochanowski University in Kielce, Kielce, Poland
- Wojciech Rokita
- 5Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, Kielce, Poland
- Jakub Młodawski
- 4Collegium Medicum, Jan Kochanowski University in Kielce, Kielce, Poland
- Jakub Młodawski
- 5Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, Kielce, Poland
- Maria Szubert
- 6Department of Gynecology and Obstetrics, Medical University of Lodz, Lodz, Poland
- Maria Szubert
- 7Department of Surgical Gynecology and Oncology, Medical University of Lodz, Lodz, Poland
- Piotr Sieroszewski
- 6Department of Gynecology and Obstetrics, Medical University of Lodz, Lodz, Poland
- Piotr Sieroszewski
- 8Department of Fetal Medicine and Gynecology, Medical University of Lodz, Lodz, Poland
- Grzegorz Raba
- 9Clinic of Obstetric and Gynecology in Przemysl, Przemysl, Poland
- Grzegorz Raba
- 0Medical College of Rzeszow University, Rzeszow, Poland
- Kamil Szczupak
- 9Clinic of Obstetric and Gynecology in Przemysl, Przemysl, Poland
- Kamil Szczupak
- 0Medical College of Rzeszow University, Rzeszow, Poland
- Tomasz Kluza
- 1Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland
- Marek Kluza
- 1Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland
- Piotr Pierzyński
- OVIklinika Infertility Center, Warsaw, Poland
- Cezary Wojtyla
- OVIklinika Infertility Center, Warsaw, Poland
- Cezary Wojtyla
- 2Women’s Health Research Institute, Calisia University, Kalisz, Poland
- Michal Lipa
- 3Departament of Obstetrics and Perinatology National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland
- Damian Warzecha
- OVIklinika Infertility Center, Warsaw, Poland
- Damian Warzecha
- 4City South Hospital, Warsaw, Warsaw, Poland
- Damian Warzecha
- 5Department of Biomedical Fundamentals of Development and Sexology, Faculty of Education, University of Warsaw, Warsaw, Poland
- Miroslaw Wielgos
- 3Departament of Obstetrics and Perinatology National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland
- Miroslaw Wielgos
- 6Premium Medical Clinic, Warsaw, Poland
- Miroslaw Wielgos
- 7Medical Faculty, Lazarski University, Warsaw, Poland
- Krzysztof Cendrowski
- Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Warsaw, Poland
- Ewa Gorodkiewicz
- Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, Bialystok, Poland
- Piotr Laudanski
- OVIklinika Infertility Center, Warsaw, Poland
- Piotr Laudanski
- Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Warsaw, Poland
- Piotr Laudanski
- 2Women’s Health Research Institute, Calisia University, Kalisz, Poland
- DOI
- https://doi.org/10.3389/fendo.2024.1359182
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundThe aim of this study was to analyze the concentration of leptin in peritoneal fluid and plasma and to assess their role as potential biomarkers in the diagnosis of endometriosis.Materials & methodsLeptin adjusted for BMI (leptin/BMI ratio) was measured using surface plasmon resonance imaging (SPRI) biosensors. Patients with suspected endometriosis were included in the study. Plasma was collected from 70 cases, and peritoneal fluid from 67 cases. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group and a control group (patients without endometriosis).ResultsLeptin/BMI ratio in plasma did not differ between women with endometriosis and the control group (0.7159 ± 0.259 vs 0.6992 ± 0.273, p= 0,7988). No significant differences were observed in peritoneal leptin/BMI ratio levels in patients with and without endometriosis (0.6206 ± 0.258 vs 0.6215 ± 0.264, p= 0,9896). Plasma and peritoneal leptin/BMI ratios were significantly lower in women with endometriosis - related primary infertility compared to women with endometriosis without primary infertility (0.640 ± 0.502 vs 0.878 ± 0.623, p < 0.05). The difference was observed in case of primary infertility, but not in terms of the secondary one. No significant differences were noted between leptin/BMI ratio in the proliferative phase and the secretory phase (0.716 ± 0.252 vs 0.697 ± 0.288, p= 0,7785).ConclusionThe results of present study do not support the relevance of leptin concentration determination as a biomarker of the endometriosis. Due to the limited number of samples in the tested group, further studies are needed to confirm its role.
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