mSphere
(Feb 2021)
Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein
Natalie M. Barber,
Clinton K. Y. Lau,
Louise Turner,
Gareth Watson,
Susan Thrane,
John P. A. Lusingu,
Thomas Lavstsen,
Matthew K. Higgins
Affiliations
Natalie M. Barber
Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Clinton K. Y. Lau
Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Louise Turner
Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark
Gareth Watson
Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Susan Thrane
Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark
John P. A. Lusingu
National Institute for Medical Research, Dar es Salaam, Tanzania
Thomas Lavstsen
ORCiD Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark
Matthew K. Higgins
ORCiD Department of Biochemistry, University of Oxford, Oxford, United Kingdom
DOI
https://doi.org/10.1128/mSphere.01081-20
Journal volume & issue
Vol. 6,
no. 1
Abstract
Read online
Vaccines train our immune systems to generate antibodies which recognize pathogens. Some of these antibodies are highly protective, preventing infection, while others are ineffective.
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