A Case of Frontotemporal Dementia with Epilepsia Partialis Continua Responding to Lacosamide Treatment

Abstract

Seizures may occur in frontotemporal lobar degeneration syndromes as an element of a heterogeneous group of disorders, according to both clinical phenotype and neuropathology. Although electroencephalography results are abnormal in frontotemporal lobar degeneration syndromes, epileptic seizures are rarely reported. A better understanding of the pathogenesis of dementia may shed light on the mechanisms of epileptogenesis and may facilitate more rational approaches to seizure treatment. The treatment of seizures in dementia syndromes is still empiric. Epilepsia partialis continua (EPC) is included in the 2001 International League Against Epilepsy (ILAE) classification as a continuous type of seizure. According to the 2017 ILAE classification, the present patient’s seizure was defined as a focal onset, preserved consciousness, focal motor, clonic seizure. The onset of epilepsia partialis continua is usually a bad predictor of progressive disease. Furthermore, there is often a failure to respond to combined high dose antiepileptics, regardless of the underlying cause.