A case of mesenteric vein thrombosis developed in the first trimester of pregnancy after in vitro fertilization and embryo transfer in a patient with antiphospholipid syndrome

Abstract

Combined thrombophilia is known as a probable cause of recurrent in vitro fertilization (IVF) failures. The present clinical case demonstrates the importance of considering the possibility of inherited or acquired thrombophilia in patients under the preparation for IVF. Thromboses of rare locations (hepatic vein, splenic vein, mesenteric vein, ovarian vein, retinal vein, cerebral vein, portal vein, axillary and subclavian vein) are life-threatening conditions. Most often thrombosis of atypical location develops in patients with inherited hemostatic defects, e.g. genetic thrombophilia. Such thromboses can also result from acquired abnormalities of hemostasis, which include antiphospholipid syndrome, pregnancy-associated hypercoagulability, IVF, oral contraception, or ovarian hyper-stimulation within IVF procedures.

Keywords

• in vitro fertilization
• thrombophilia
• antiphospholipid antibodies
• ivf implantation failure
• assisted reproductive technologies
• thrombosis