Prognostic significance of β2-microglobulin decline index in multiple myeloma

Tianyu Zhang; Tianyu Zhang; Zhili Lin; Ziwei Zheng; Quanqiang Wang; Shujuan Zhou; Bingxin Zhang; Dong Zheng; Zixing Chen; Sisi Zheng; Yu Zhang; Xuanru Lin; Rujiao Dong; Jingjing Chen; Honglan Qian; Xudong Hu; Yan Zhuang; Qianying Zhang; Zhouxiang Jin; Songfu Jiang; Yongyong Ma; Yongyong Ma; Yongyong Ma

doi:10.3389/fonc.2024.1322680

Frontiers in Oncology (Mar 2024)

Prognostic significance of β2-microglobulin decline index in multiple myeloma

Tianyu Zhang,
Tianyu Zhang,
Zhili Lin,
Ziwei Zheng,
Quanqiang Wang,
Shujuan Zhou,
Bingxin Zhang,
Dong Zheng,
Zixing Chen,
Sisi Zheng,
Yu Zhang,
Xuanru Lin,
Rujiao Dong,
Jingjing Chen,
Honglan Qian,
Xudong Hu,
Yan Zhuang,
Qianying Zhang,
Zhouxiang Jin,
Songfu Jiang,
Yongyong Ma,
Yongyong Ma,
Yongyong Ma

Affiliations

Tianyu Zhang: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Tianyu Zhang: Department of Neurology, The First People’s Hospital of Fuyang District, Hangzhou, Zhejiang, China
Zhili Lin: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Ziwei Zheng: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Quanqiang Wang: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Shujuan Zhou: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Bingxin Zhang: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Dong Zheng: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Zixing Chen: Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Sisi Zheng: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Yu Zhang: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Xuanru Lin: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Rujiao Dong: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Jingjing Chen: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Honglan Qian: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Xudong Hu: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Yan Zhuang: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Qianying Zhang: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Zhouxiang Jin: Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Songfu Jiang: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Yongyong Ma: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Yongyong Ma: The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Province, Wenzhou, Zhejiang, China
Yongyong Ma: The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Engineering Research Center for Hospital Emergency and Process Digitization, Wenzhou, Zhejiang, China

DOI: https://doi.org/10.3389/fonc.2024.1322680
Journal volume & issue: Vol. 14

Abstract

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PurposeTo assess the prognostic significance of β2-microglobulin decline index (β2M DI) in multiple myeloma (MM).Methods150 MM patients diagnosed with MM were enrolled in this study. Cox proportional hazards model was used to analyze the uni- and multivariate prognosis in training cohort (n=105). A new combined prognostic model containing β2M DI was built up based on the data in training cohort. The validation group was used to verify the model.Resultsβ2M DI showed significant correlation with prognosis in both uni- and multivariate analyses and had a good correlation with complete response (CR) rate and deep remission rate. The ROC and calibration curves in validation cohort (n=45) indicated a good predictive performance of the new model. Based on the median risk score of the training group, we classified patients into high- and low- risk groups. In both training and validation groups, patients in the low-risk group had longer overall survival (OS) time than that in the high-risk group (p<0.05).Conclusionβ2M DI is a good predictive index for predicting treatment response and survival time in MM patients. The prognostic model added with β2M DI showed a better correlation with OS.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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