Histopathological Study of Primary Bone Tumours and Tumour-Like Lesions in a Medical Teaching Hospital

Abstract

Objectives: Histopathological study of bone tumours to determine the spectrum of bone tumours at a Medical teaching Hospital and to correlate it with demographic features like age, sex of patients and anatomical site of tumours. Material and Methods: A retrospective and prospective study of all histopathologically diagnosed bone tumours over a period of 10 years was done. Patients were assessed by clinical examination, radiological investigations, histopathological examination and fine needle aspiration cytology (FNAC) whenever available. Results: A total of eighty-two cases of primary bone tumours were recorded, of which benign tumours were the most common 62 cases (75.61%) followed by malignant tumours with 13 cases (15.85%) and 7 cases (8.54%) of tumour-like lesions. FNAC diagnosis was available in 26 cases (31.71 %) with 68.96 % benign tumours, 17.24% malignant and 3.45% were tumour– like lesions. The concordance and discordance rate of histopathological diagnosis was 76.93% and 23.07 % respectively. On histopathological diagnosis, the most common benign tumour was osteochondroma 34.15% followed by Giant cell tumour 19.51%. Osteosarcoma was commonest malignant tumour 8.54%. Maximum number of bone tumours occurred in 11-20 years of age and the male to female ratio was 1.2:1. Conclusions: Bone tumours occurredpredominantly in the second decade of life with a male preponderance. Osteochondroma was the most common benign tumour followed by Giant cell tumour and Osteosarcoma was the most common malignant bone tumour.

Keywords

• Bone tumours
• Histopathology
• Giant cell tumour
• Osteochondroma
• Osteosarcoma