Frontiers in Pharmacology (Jun 2024)
Critical roles of lncRNA-mediated autophagy in urologic malignancies
- Lifeng Gan,
- Lifeng Gan,
- Lifeng Gan,
- Liying Zheng,
- Junrong Zou,
- Junrong Zou,
- Peiyue Luo,
- Peiyue Luo,
- Peiyue Luo,
- Tao Chen,
- Tao Chen,
- Tao Chen,
- Jun Zou,
- Jun Zou,
- Jun Zou,
- Wei Li,
- Wei Li,
- Wei Li,
- Qi Chen,
- Qi Chen,
- Qi Chen,
- Le Cheng,
- Le Cheng,
- Le Cheng,
- Fangtao Zhang,
- Fangtao Zhang,
- Fangtao Zhang,
- Biao Qian,
- Biao Qian
Affiliations
- Lifeng Gan
- The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China
- Lifeng Gan
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Lifeng Gan
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Liying Zheng
- Department of Graduate, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Junrong Zou
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Junrong Zou
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Peiyue Luo
- The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China
- Peiyue Luo
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Peiyue Luo
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Tao Chen
- The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China
- Tao Chen
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Tao Chen
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Jun Zou
- The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China
- Jun Zou
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Jun Zou
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Wei Li
- The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China
- Wei Li
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Wei Li
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Qi Chen
- The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China
- Qi Chen
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Qi Chen
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Le Cheng
- The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China
- Le Cheng
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Le Cheng
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Fangtao Zhang
- The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China
- Fangtao Zhang
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Fangtao Zhang
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- Biao Qian
- Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- Biao Qian
- Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China
- DOI
- https://doi.org/10.3389/fphar.2024.1405199
- Journal volume & issue
-
Vol. 15
Abstract
Urologic oncology is a significant public health concern on a global scale. Recent research indicates that long chain non-coding RNAs (lncRNAs) and autophagy play crucial roles in various cancers, including urologic malignancies. This article provides a summary of the latest research findings, suggesting that lncRNA-mediated autophagy could either suppress or promote tumors in prostate, kidney, and bladder cancers. The intricate network involving different lncRNAs, target genes, and mediated signaling pathways plays a crucial role in urological malignancies by modulating the autophagic process. Dysregulated expression of lncRNAs can disrupt autophagy, leading to tumorigenesis, progression, and enhanced resistance to therapy. Consequently, targeting particular lncRNAs that control autophagy could serve as a dependable diagnostic tool and a promising prognostic biomarker in urologic oncology, while also holding potential as an effective therapeutic approach.
Keywords
