Communications Biology (Apr 2021)
Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast
- Satoi Nagasawa,
- Yuta Kuze,
- Ichiro Maeda,
- Yasuyuki Kojima,
- Ai Motoyoshi,
- Tatsuya Onishi,
- Tsuguo Iwatani,
- Takamichi Yokoe,
- Junki Koike,
- Motohiro Chosokabe,
- Manabu Kubota,
- Hibiki Seino,
- Ayako Suzuki,
- Masahide Seki,
- Katsuya Tsuchihara,
- Eisuke Inoue,
- Koichiro Tsugawa,
- Tomohiko Ohta,
- Yutaka Suzuki
Affiliations
- Satoi Nagasawa
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Yuta Kuze
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Ichiro Maeda
- Department of Diagnostic Pathology, Kitasato University Kitasato Institute Hospital
- Yasuyuki Kojima
- Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine
- Ai Motoyoshi
- Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine
- Tatsuya Onishi
- Department of Breast Surgery, National Cancer Center Hospital East
- Tsuguo Iwatani
- Department of Breast Surgery, National Cancer Center Hospital East
- Takamichi Yokoe
- Department of Breast Surgery, National Cancer Center Hospital East
- Junki Koike
- Department of Pathology, St. Marianna University School of Medicine
- Motohiro Chosokabe
- Department of Pathology, St. Marianna University School of Medicine
- Manabu Kubota
- Department of Pathology, St. Marianna University School of Medicine
- Hibiki Seino
- Department of Pathology, St. Marianna University School of Medicine
- Ayako Suzuki
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Masahide Seki
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Katsuya Tsuchihara
- Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center
- Eisuke Inoue
- Showa University Research Administration Center, Showa University
- Koichiro Tsugawa
- Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine
- Tomohiko Ohta
- Department of Translational Oncology, St. Marianna University Graduate School of Medicine
- Yutaka Suzuki
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- DOI
- https://doi.org/10.1038/s42003-021-01959-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Satoi Nagasawa and Yuta Kuze et al. report a multi-omic analysis of ductal carcinoma in situ (DCIS) of the breast, including whole-exome, single-cell, and spatial transcriptome sequencing. They find that for patients under 45 years of age, HER2 amplification and GATA3 mutation are associated with higher risk of relapse, suggesting they could be used as predictive markers when deciding on a treatment course.
