Nature Communications (May 2020)
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
- Katarína Tiklová,
- Sara Nolbrant,
- Alessandro Fiorenzano,
- Åsa K. Björklund,
- Yogita Sharma,
- Andreas Heuer,
- Linda Gillberg,
- Deirdre B. Hoban,
- Tiago Cardoso,
- Andrew F. Adler,
- Marcella Birtele,
- Hilda Lundén-Miguel,
- Nikolaos Volakakis,
- Agnete Kirkeby,
- Thomas Perlmann,
- Malin Parmar
Affiliations
- Katarína Tiklová
- Ludwig Institute for Cancer Research
- Sara Nolbrant
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Alessandro Fiorenzano
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Åsa K. Björklund
- Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University
- Yogita Sharma
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Andreas Heuer
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Linda Gillberg
- Ludwig Institute for Cancer Research
- Deirdre B. Hoban
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Tiago Cardoso
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Andrew F. Adler
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Marcella Birtele
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Hilda Lundén-Miguel
- Ludwig Institute for Cancer Research
- Nikolaos Volakakis
- Ludwig Institute for Cancer Research
- Agnete Kirkeby
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- Thomas Perlmann
- Ludwig Institute for Cancer Research
- Malin Parmar
- Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University
- DOI
- https://doi.org/10.1038/s41467-020-16225-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-clinical rat model for Parkinson’s disease and identify perivascular-like cells.
