Evaluation of adrenaline auto-injector prescription profiles: A population-based, retrospective cohort study within the National Insurance Claims Database of Japan

Sakura Sato; Keigo Kainuma; Tatsuya Noda; Motohiro Ebisawa; Masaki Futamura; Tomoaki Imamura; Akihiro Miyagawa; Saeko Nakajima; Yasushi Ogawa; Takenori Inomata; Keiko Kan-o; Yosuke Kurashima; Katsunori Masaki; Tomoya Myojin; Yuichi Nishioka; Masafumi Sakashita; Mayumi Tamari; Hideaki Morita; Takeya Adachi

Allergology International (Jul 2022)

Evaluation of adrenaline auto-injector prescription profiles: A population-based, retrospective cohort study within the National Insurance Claims Database of Japan

Sakura Sato,
Keigo Kainuma,
Tatsuya Noda,
Motohiro Ebisawa,
Masaki Futamura,
Tomoaki Imamura,
Akihiro Miyagawa,
Saeko Nakajima,
Yasushi Ogawa,
Takenori Inomata,
Keiko Kan-o,
Yosuke Kurashima,
Katsunori Masaki,
Tomoya Myojin,
Yuichi Nishioka,
Masafumi Sakashita,
Mayumi Tamari,
Hideaki Morita,
Takeya Adachi

Affiliations

Sakura Sato: ENGAGE NDB Task Force, Tokyo, Japan; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan
Keigo Kainuma: ENGAGE NDB Task Force, Tokyo, Japan; Institute for Clinical Research, National Hospital Organization, Mie National Hospital, Mie, Japan
Tatsuya Noda: Department of Public Heath, Health Management and Policy, Nara Medical University, Nara, Japan
Motohiro Ebisawa: Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan
Masaki Futamura: ENGAGE NDB Task Force, Tokyo, Japan; Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Aichi, Japan
Tomoaki Imamura: Department of Public Heath, Health Management and Policy, Nara Medical University, Nara, Japan
Akihiro Miyagawa: Department of Dermatology, Kawasaki Municipal Hospital, Kanagawa, Japan
Saeko Nakajima: ENGAGE NDB Task Force, Tokyo, Japan; Department of Drug Discovery for Inflammatory Skin Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan
Yasushi Ogawa: Department of Advanced Medicine, Department of Dermatology, Nagoya University Hospital, Nagoya, Japan
Takenori Inomata: ENGAGE NDB Task Force, Tokyo, Japan; Department of Ophthalmology | Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
Keiko Kan-o: ENGAGE NDB Task Force, Tokyo, Japan; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Yosuke Kurashima: ENGAGE NDB Task Force, Tokyo, Japan; Department of Mucosal Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
Katsunori Masaki: ENGAGE NDB Task Force, Tokyo, Japan; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
Tomoya Myojin: Department of Public Heath, Health Management and Policy, Nara Medical University, Nara, Japan
Yuichi Nishioka: Department of Public Heath, Health Management and Policy, Nara Medical University, Nara, Japan
Masafumi Sakashita: ENGAGE NDB Task Force, Tokyo, Japan; Department of Otorhinolaryngology Head and Neck Surgery, University of Fukui, Fukui, Japan
Mayumi Tamari: Division of Molecular Genetics, The Jikei University School of Medicine, Research Center for Medical Science, Tokyo, Japan
Hideaki Morita: ENGAGE NDB Task Force, Tokyo, Japan; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan; Allergy Center, National Center for Child Health and Development, Tokyo, Japan; Corresponding author. Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535 Japan.
Takeya Adachi: ENGAGE NDB Task Force, Tokyo, Japan; Department of Medical Regulatory Science, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan; Keio Frontier Research & Education Collaborative Square (K-FRECS) at Tonomachi, Keio University, Kanagawa, Japan; Department of Dermatology, Tachikawa Hospital, Federation of National Public Service Personnel Mutual Aid Associations, Tokyo, Japan; Corresponding author. Department of Medical Regulatory Science, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

Journal volume & issue: Vol. 71, no. 3
pp. 354 – 361

Abstract

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Background: Adrenaline is the first-line medication for managing anaphylaxis. A better understanding of prescription trends for adrenaline auto-injectors (AAIs) is important to improving patient care as well as information on health education interventions and medical guidelines. However, it has been difficult to gather comprehensive data in a sustainable manner. Thus, we aimed to investigate trends in AAI prescriptions in Japan. Methods: We searched the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), a unique and comprehensive database of health insurance claims, and investigated prescriptions for AAIs for all ages (April 2017 to March 2018). We assessed the annual number of prescriptions per person as well as prescription rates per 100,000 population per year by age, sex, and geographic region. Results: A total of 88,039 subjects (56,109 males, 31,930 female) and 116,758 devices (1.33 AAIs per patient per year) were prescribed AAIs at least once a year for all ages. The prescription rate for AAIs was 69.5 per 100,000 population-years. Patients aged 0–9 years were prescribed AAIs at the rate of 278.9 per 100,000 population-years. Patients aged 0–19 years were 6.4 times more likely to be prescribed AAIs than those over 20 years of age. Males were more frequently prescribed AAIs than females in all age groups, except for those aged 20–24 years. We also evaluated differences in prescription rates by geographic region. Conclusions: This comprehensive evaluation revealed trends in AAI prescriptions, thus helping develop preventive strategies with respect to anaphylaxis in Japan.

Published in Allergology International

ISSN: 1323-8930 (Print); 1440-1592 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.journals.elsevier.com/allergology-international/

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