Journal of Integrative Agriculture (Aug 2020)
Alphaherpesvirus-vectored vaccines against animal diseases: Current progress
- Yang HU,
- Ming-shu WANG,
- An-chun CHENG,
- Ren-yong JIA,
- Qiao YANG,
- Ying WU,
- Ma-feng LIU,
- Xin-xin ZHAO,
- De-kang ZHU,
- Shun CHEN,
- Sha-qiu ZHANG,
- Yin WANG,
- Qun GAO,
- Xu-min OU,
- Sai MAO,
- Xing-jian WEN,
- Zhi-wen XU,
- Zheng-li CHEN,
- Ling ZHU,
- Qi-hui LUO,
- Bin TIAN,
- Lei-chang PAN,
- Mujeeb Ur REHMAN,
- Yun-ya LIU,
- Yan-ling YU,
- Ling ZHANG,
- Xiao-yue CHEN
Affiliations
- Yang HU
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Correspondence HU Yang
- Ming-shu WANG
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- An-chun CHENG
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Correspondence CHENG An-chun
- Ren-yong JIA
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Qiao YANG
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Ying WU
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Ma-feng LIU
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Xin-xin ZHAO
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- De-kang ZHU
- Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Shun CHEN
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Sha-qiu ZHANG
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Yin WANG
- Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Qun GAO
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Xu-min OU
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Sai MAO
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Xing-jian WEN
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Zhi-wen XU
- Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Zheng-li CHEN
- Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Ling ZHU
- Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Qi-hui LUO
- Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Bin TIAN
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Lei-chang PAN
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Mujeeb Ur REHMAN
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Yun-ya LIU
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Yan-ling YU
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Ling ZHANG
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Xiao-yue CHEN
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
- Journal volume & issue
-
Vol. 19,
no. 8
pp. 1928 – 1940
Abstract
Recombinant virus-vectored vaccines are novel agents that can effectively activate specific and nonspecific immunity, are multivalent and multieffective, and have high safety ratings. Animal alphaherpesviruses have a large genome, contain multiple nonessential regions that do not affect viral replication and are capable of accepting the insertion of an exogenous gene and expressing the antigen protein. Furthermore, animal alphaherpesviruses have a wide host spectrum, can replicate in the host and continuously stimulate the animal to produce immunity to the corresponding pathogen, thus making them ideal carriers for recombinant virus-vectored vaccines. With the development of gene-editing technology, recombinant viruses capable of expressing foreign genes can be constructed by various methods. Currently, studies on recombinant virus-vectored vaccines constructed based on animal alphaherpesviruses have involved poultry, pigs, cattle, sheep, and companion animals. Studies have shown that the construction of recombinant animal alphaherpesviruses enables the acquisition of immunity to multiple diseases. This article mainly summarizes the current progress on animal alphaherpesvirus-vectored vaccines, aiming to provide reference for the development of new animal alphaherpesvirus-vectored vaccines.
