Insc:LGN tetramers promote asymmetric divisions of mammary stem cells

Simone Culurgioni; Sara Mari; Paola Bonetti; Sara Gallini; Greta Bonetto; Martha Brennich; Adam Round; Francesco Nicassio; Marina Mapelli

doi:10.1038/s41467-018-03343-4

Nature Communications (Mar 2018)

Insc:LGN tetramers promote asymmetric divisions of mammary stem cells

Simone Culurgioni,
Sara Mari,
Paola Bonetti,
Sara Gallini,
Greta Bonetto,
Martha Brennich,
Adam Round,
Francesco Nicassio,
Marina Mapelli

Affiliations

Simone Culurgioni: Department of Experimental Oncology, European Institute of Oncology
Sara Mari: Department of Experimental Oncology, European Institute of Oncology
Paola Bonetti: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT)
Sara Gallini: Department of Experimental Oncology, European Institute of Oncology
Greta Bonetto: Department of Experimental Oncology, European Institute of Oncology
Martha Brennich: European Molecular Biology Laboratory, Grenoble Outstation
Adam Round: European Molecular Biology Laboratory, Grenoble Outstation
Francesco Nicassio: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT)
Marina Mapelli: Department of Experimental Oncology, European Institute of Oncology

DOI: https://doi.org/10.1038/s41467-018-03343-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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During asymmetric divisions fate determinants and niche contacts segregate unequally between daughter cells, but the mechanism is unclear. Here the authors show that Insc:LGN tetramers promote assembly of Par3-Insc-LGN-GαiGDP complexes and asymmetric fate specification independently of microtubule motors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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