H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation

Abstract

Here the authors investigated the direct collaboration between ubiquitinated histone H2B (ubH2B) with FACT at the nucleosome level. They found ubH2B enhances FACT’s chaperone property, recruits FACT to form a stable altered nucleosome state, and provides a key platform for transcription.