Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Pooja Munnilal Tiwari; Daryll Vanover; Kevin E. Lindsay; Swapnil Subhash Bawage; Jonathan L. Kirschman; Sushma Bhosle; Aaron W. Lifland; Chiara Zurla; Philip J. Santangelo

doi:10.1038/s41467-018-06508-3

Nature Communications (Oct 2018)

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Pooja Munnilal Tiwari,
Daryll Vanover,
Kevin E. Lindsay,
Swapnil Subhash Bawage,
Jonathan L. Kirschman,
Sushma Bhosle,
Aaron W. Lifland,
Chiara Zurla,
Philip J. Santangelo

Affiliations

Pooja Munnilal Tiwari: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Daryll Vanover: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Kevin E. Lindsay: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Swapnil Subhash Bawage: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Jonathan L. Kirschman: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Sushma Bhosle: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Aaron W. Lifland: Institute of Bioengineering and Bioscience, Georgia Institute of Technology
Chiara Zurla: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Philip J. Santangelo: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

DOI: https://doi.org/10.1038/s41467-018-06508-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Engineered neutralizing antibodies are potential therapeutics for numerous viruses, such as respiratory syncytial virus (RSV). Here, the authors develop an mRNA-based approach to express membrane-anchored neutralizing antibodies in the lung and demonstrate that it inhibits RSV infections in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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