Indian Journal of Dermatology (Jan 2016)

Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis

  • Subramanian Kumudhini,
  • Raghavendra Rao,
  • Gauri Salgaonkar,
  • Sricharith Shetty,
  • Sathish Pai

DOI
https://doi.org/10.4103/0019-5154.190134
Journal volume & issue
Vol. 61, no. 5
pp. 581 – 581

Abstract

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Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direct immunofluorescence microscopy of perilesional skin revealed nonspecific deposition of IgM in granular pattern along the dermoepidermal junction.

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