Nature Communications (Nov 2017)
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding
- Daniel W. Kulp,
- Jon M. Steichen,
- Matthias Pauthner,
- Xiaozhen Hu,
- Torben Schiffner,
- Alessia Liguori,
- Christopher A. Cottrell,
- Colin Havenar-Daughton,
- Gabriel Ozorowski,
- Erik Georgeson,
- Oleksandr Kalyuzhniy,
- Jordan R. Willis,
- Michael Kubitz,
- Yumiko Adachi,
- Samantha M. Reiss,
- Mia Shin,
- Natalia de Val,
- Andrew B. Ward,
- Shane Crotty,
- Dennis R. Burton,
- William R. Schief
Affiliations
- Daniel W. Kulp
- Department of Immunology and Microbiology, The Scripps Research Institute
- Jon M. Steichen
- Department of Immunology and Microbiology, The Scripps Research Institute
- Matthias Pauthner
- Department of Immunology and Microbiology, The Scripps Research Institute
- Xiaozhen Hu
- Department of Immunology and Microbiology, The Scripps Research Institute
- Torben Schiffner
- Department of Immunology and Microbiology, The Scripps Research Institute
- Alessia Liguori
- Department of Immunology and Microbiology, The Scripps Research Institute
- Christopher A. Cottrell
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Colin Havenar-Daughton
- Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
- Gabriel Ozorowski
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Erik Georgeson
- Department of Immunology and Microbiology, The Scripps Research Institute
- Oleksandr Kalyuzhniy
- Department of Immunology and Microbiology, The Scripps Research Institute
- Jordan R. Willis
- Department of Immunology and Microbiology, The Scripps Research Institute
- Michael Kubitz
- Department of Immunology and Microbiology, The Scripps Research Institute
- Yumiko Adachi
- Department of Immunology and Microbiology, The Scripps Research Institute
- Samantha M. Reiss
- Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
- Mia Shin
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Natalia de Val
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Andrew B. Ward
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Shane Crotty
- Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
- Dennis R. Burton
- Department of Immunology and Microbiology, The Scripps Research Institute
- William R. Schief
- Department of Immunology and Microbiology, The Scripps Research Institute
- DOI
- https://doi.org/10.1038/s41467-017-01549-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Eliciting broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal, but available immunogens expose epitopes for development of non-nAbs. Here, the authors use computational and structure-guided design to develop improved native-like envelope trimers and analyze Ab response in animal models.
