Regulation of host immune responses by Lactobacillus through aryl hydrocarbon receptors

Zhipeng Huang; Liwei Xie; Liping Huang

Medicine in Microecology (Jun 2023)

Regulation of host immune responses by Lactobacillus through aryl hydrocarbon receptors

Zhipeng Huang,
Liwei Xie,
Liping Huang

Affiliations

Zhipeng Huang: Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, China
Liwei Xie: State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, China; School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China; Corresponding author. State Key Laboratory of Applied Microbiology Southern China Institute of Microbiology, Guangdong Academy of Science 100 Xianlie Middle Rd. BLD58 2nd Floor Guangzhou, Guangdong, 510070, China.
Liping Huang: Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Corresponding author.

Journal volume & issue: Vol. 16
p. 100081

Abstract

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The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that serves as a key environmental sensor and mechanistic regulator of both the epithelial barrier and systemic immunity. Exogenous ligands (aromatic compounds such as dioxins) and endogenous ligands (tryptophan and its metabolite family) are the two types of AhR ligands. In particular, certain gut flora contain enzymes involved in the metabolism of tryptophan to AhR ligands, and Lactobacillus is attractive among all intestinal flora which are capable of producing AhR ligands. This research reviews the probiotic effects of Lactobacillus reuteri and other Lactobacilli on immunological responses and gut barrier function via the AhR pathway, and it also provides evidence to support the probiotics as an alternative therapy for some specific diseases in the future.

Published in Medicine in Microecology

ISSN: 2590-0978 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology; Science: Microbiology
Website: https://www.journals.elsevier.com/medicine-in-microecology/

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