Differential diagnosis difficulties of focal central nervous system damage in children (а сlinical case)

Abstract

Focal central nervous system damage can be a result of infectious process in brain or spinal cord, autoimmune or hypoxic-ischemic process and a relationship of these processes. Difficulties in differential diagnosis of variant pathogenic focuses in central nervous system are related with absence of specific clinical and laboratory data. In such cases brain biopsy can help to make right diagnosis. In this article we characterized diagnostical process in teenage girl with progressive case of acute disseminated encephalomyelitis and vegetative status as complication, though she got large doses of steroids and intravenous immunoglobulins at the disease onset, with positive dynamic as a result of prolonged antiviral therapy. The diagnosis was made only by brain biopsy – we found herpesviral brain damage, further the disease transformed in multiple sclerosis.

Keywords

• дети
• очаговое поражение центральной нервной системы
• герпесвирусы
• острый диссеминированный энцефаломиелит
• рассеянный склероз
• демиелинизирующие заболевания
• магнитно-резонансная томография