Nature Communications (Mar 2020)

Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver

  • Sabrina Jabs,
  • Anne Biton,
  • Christophe Bécavin,
  • Marie-Anne Nahori,
  • Amine Ghozlane,
  • Alessandro Pagliuso,
  • Giulia Spanò,
  • Vincent Guérineau,
  • David Touboul,
  • Quentin Giai Gianetto,
  • Thibault Chaze,
  • Mariette Matondo,
  • Marie-Agnès Dillies,
  • Pascale Cossart

DOI
https://doi.org/10.1038/s41467-020-15126-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The intestinal microbiota modulates host physiology and gene expression via unclear mechanisms. Here, Jabs et al. show that variations in the gut microbiota correlate with N6-methyladenosine modifications of host mRNAs in the cecum and liver of mice.