Molecules (Jul 2014)

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

  • Marcus Baumann,
  • Ian R. Baxendale,
  • Christian H. Hornung,
  • Steven V. Ley,
  • Maria Victoria Rojo,
  • Kimberley A. Roper

DOI
https://doi.org/10.3390/molecules19079736
Journal volume & issue
Vol. 19, no. 7
pp. 9736 – 9759

Abstract

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Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.

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