Nature Communications (Jan 2018)
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo
- Ralf Gilsbach,
- Martin Schwaderer,
- Sebastian Preissl,
- Björn A. Grüning,
- David Kranzhöfer,
- Pedro Schneider,
- Thomas G. Nührenberg,
- Sonia Mulero-Navarro,
- Dieter Weichenhan,
- Christian Braun,
- Martina Dreßen,
- Adam R. Jacobs,
- Harald Lahm,
- Torsten Doenst,
- Rolf Backofen,
- Markus Krane,
- Bruce D. Gelb,
- Lutz Hein
Affiliations
- Ralf Gilsbach
- Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg
- Martin Schwaderer
- Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg
- Sebastian Preissl
- Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg
- Björn A. Grüning
- Bioinformatics Group, Department of Computer Science, University of Freiburg
- David Kranzhöfer
- Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg
- Pedro Schneider
- Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg
- Thomas G. Nührenberg
- Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg
- Sonia Mulero-Navarro
- The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai
- Dieter Weichenhan
- Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- Christian Braun
- Forensic Institute, Ludwig-Maximilians-University
- Martina Dreßen
- Department of Cardiovascular Surgery, German Heart Center, Technische Universität München
- Adam R. Jacobs
- Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai
- Harald Lahm
- Department of Cardiovascular Surgery, German Heart Center, Technische Universität München
- Torsten Doenst
- Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University
- Rolf Backofen
- Bioinformatics Group, Department of Computer Science, University of Freiburg
- Markus Krane
- Department of Cardiovascular Surgery, German Heart Center, Technische Universität München
- Bruce D. Gelb
- The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai
- Lutz Hein
- Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-017-02762-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
How the cardiac myocyte epigenome is rearranged during development, postnatal maturation and disease is not well understood. Here, the authors investigate the human cardiac myocyte epigenome during development and chronic heart failure and identify distinct epigenetic programs regulating these processes.
