Nature Communications (Jun 2017)

Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions

  • Yongzhi Qiu,
  • Sheng Tong,
  • Linlin Zhang,
  • Yumiko Sakurai,
  • David R. Myers,
  • Lin Hong,
  • Wilbur A. Lam,
  • Gang Bao

DOI
https://doi.org/10.1038/ncomms15594
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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The transportation of large molecules through the vascular endothelium presents a major challenge forin vivodrug delivery. Here, the authors demonstrate the potential of using external magnetic fields and magnetic nanoparticles to enhance the local extravasation of circulating large molecules.