Simultaneous Determination of Sodium Pentachlorophenolate and Its Metabolites in Swine Samples

Qi Jia; Miao Cui; Meiling Li; Yuncheng Li; Fanbing Meng; Yanyang Xu; Yongzhong Qian; Xue Yan; Jing Qiu

doi:10.3390/separations10100537

Separations (Oct 2023)

Simultaneous Determination of Sodium Pentachlorophenolate and Its Metabolites in Swine Samples

Qi Jia,
Miao Cui,
Meiling Li,
Yuncheng Li,
Fanbing Meng,
Yanyang Xu,
Yongzhong Qian,
Xue Yan,
Jing Qiu

Affiliations

Qi Jia: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Miao Cui: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Meiling Li: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Yuncheng Li: College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
Fanbing Meng: College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
Yanyang Xu: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Yongzhong Qian: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Xue Yan: Key Laboratory of Feed and Livestock and Poultry Products Quality & Safety Control, New Hope Liuhe Co., Ltd., Chengdu 610023, China
Jing Qiu: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China

DOI: https://doi.org/10.3390/separations10100537
Journal volume & issue: Vol. 10, no. 10
p. 537

Abstract

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Pentachlorophenol (PCP) is a persistent organic pollutant usually present in the form of sodium salts (PCP-Na) that has been banned for many years, but it can still be detected in animal food. The present study established a method of detecting PCP-Na and its metabolites—tetrachlorocatechol (TCC), pentachlorophenol acetate (PCP-acetate), and pentachloroanisole (PCA)—in swine samples (pork, fat, liver, heart, lungs and kidney), simultaneously using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS) based on the modified QuEChERS pre-treatment method. The validation results exhibited a good sensitivity with limits of quantitation (LOQs) of 1 μg/kg–2 μg/kg. The recoveries of spiked samples were in the range of 60.5–119.9%, with a relative standard deviation (RSD) between replicates (n = 5) of between 0.70% and 12.06%.

Published in Separations

ISSN: 2297-8739 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/separations

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