Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease

Bo Li; Yitong Yang; Yingxin Wang; Didi Shan; Jianing Li; Hongxu Wang; Xiaohan Sun; Yao Tang; Yichang Jiao; Xinbo Ji; Zexin Zhan; Bo Kong; Bo Gao; Yu Wang; Ping Sun; Fuchen Liu

doi:10.1016/j.scr.2024.103638

Stem Cell Research (Feb 2025)

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease

Bo Li,
Yitong Yang,
Yingxin Wang,
Didi Shan,
Jianing Li,
Hongxu Wang,
Xiaohan Sun,
Yao Tang,
Yichang Jiao,
Xinbo Ji,
Zexin Zhan,
Bo Kong,
Bo Gao,
Yu Wang,
Ping Sun,
Fuchen Liu

Affiliations

Bo Li: Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China
Yitong Yang: School of Nursing, Jining Medical University, Jining, Shandong, China
Yingxin Wang: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Didi Shan: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Jianing Li: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Hongxu Wang: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Xiaohan Sun: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Yao Tang: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Yichang Jiao: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Xinbo Ji: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Zexin Zhan: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Bo Kong: Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China
Bo Gao: Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China
Yu Wang: Prenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, China
Ping Sun: Prenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, China
Fuchen Liu: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China; Corresponding author.

DOI: https://doi.org/10.1016/j.scr.2024.103638
Journal volume & issue: Vol. 82
p. 103638

Abstract

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Abnormal trinucleotide CAG repeat expansions in exon 1 of the Androgen Receptor (AR) gene has been identified as the cause of Kennedy disease (KD). We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with genetically confirmed KD. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.sciencedirect.com/journal/stem-cell-research

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