Spontaneous bone infarction of the distal femur in a patient with Cushing's disease: a case report
Pepijn van Houten,
Jacky de Rooy,
Ingrid van der Geest,
Romana Netea-Maier,
Annenienke van de Ven
Affiliations
Pepijn van Houten
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, Nijmegen, the Netherlands
Jacky de Rooy
Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands
Ingrid van der Geest
Department of Orthopedic Oncologic Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands
Romana Netea-Maier
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, Nijmegen, the Netherlands
Annenienke van de Ven
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, Nijmegen, the Netherlands; Corresponding author at: Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, PO box 9101, 6500 HB Nijmegen, the Netherlands.
Avascular necrosis of the femoral head is a well-known complication of treatment with high dosage glucocorticoids and has been described in a few patients with Cushing's syndrome. In this case report, we describe the, to our knowledge, first case of a patient with endogenous Cushing's syndrome with a bone infarction located in the distal femur. In patients with Cushing's syndrome and bone pain, the diagnosis of bone infarction should be considered as it can occur as a rare complication of hypercortisolism.
