Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan
Masanori Isobe
Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan
Ryo Mishima
Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan
Keima Tose
Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan
Michiko Kawabata
Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan
Toshihiko Aso
Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Japan
Shisei Tei
Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan; and School of Human and Social Sciences, Tokyo International University, Japan
Shun'ichi Noma
Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan; and Department of Psychiatry, Nomakokoro Clinic, Japan
Toshiya Murai
Department of Psychiatry, Kyoto University Graduate School of Medicine, Japan
We examined the neural underpinnings of the effects of mindfulness on anxiety in anorexia nervosa using functional magnetic resonance imaging in 21 anorexia patients. We used a functional magnetic resonance imaging task designed to induce weight-related anxiety and asked participants to regulate their anxiety either using or not using an acceptance strategy. Our results showed reduced activity in the amygdala, anterior cingulate cortex, putamen, caudate, orbital gyrus, middle frontal gyrus, posterior cingulate cortex and precuneus following a mindfulness-based intervention. The present study provides new insight regarding the neural mechanisms underlying the effect of mindfulness-based intervention in ameliorating anorexia nervosa.
