Communications Biology (Nov 2020)

Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation

  • Michal Schwartz,
  • Avital Sarusi Portugez,
  • Bracha Zukerman Attia,
  • Miriam Tannenbaum,
  • Leslie Cohen,
  • Olga Loza,
  • Emily Chase,
  • Yousef Turman,
  • Tommy Kaplan,
  • Zaidoun Salah,
  • Ofir Hakim

DOI
https://doi.org/10.1038/s42003-020-01398-y
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 13

Abstract

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By integrating transcriptome, regulatory element and chromosome topology profiles, Schwartz et al identify redistribution of p53 and CTCF genomic binding to be associated with transcriptional and phenotypical changes during Ras-induced transformation of mammary epithelial cells.