Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break

Jieqiong Lou; David G. Priest; Ashleigh Solano; Adèle Kerjouan; Elizabeth Hinde

doi:10.1038/s41467-020-19504-3

Nature Communications (Nov 2020)

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break

Jieqiong Lou,
David G. Priest,
Ashleigh Solano,
Adèle Kerjouan,
Elizabeth Hinde

Affiliations

Jieqiong Lou: School of Physics, University of Melbourne
David G. Priest: School of Physics, University of Melbourne
Ashleigh Solano: School of Physics, University of Melbourne
Adèle Kerjouan: Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne
Elizabeth Hinde: School of Physics, University of Melbourne

DOI: https://doi.org/10.1038/s41467-020-19504-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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53BP1 is a crucial factor involved in double strand break repair which blocks DNA end resection affecting DNA repair pathway choice. Here the authors reveal by live cell nuclear architecture analysis the spatiotemporal dynamics of 53BP1 oligomerization during a DSB DNA damage response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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