Exploration of Targeted Anti-tumor Therapy (Dec 2020)

Use of liquid biopsy in monitoring therapeutic resistance in EGFR oncogene addicted NSCLC

  • Marialucia Iacovino,
  • Vincenza Ciaramella,
  • Fernando Paragliola,
  • Gabriella Suarato,
  • Gesualdina Busiello,
  • Francesca Sparano

DOI
https://doi.org/10.37349/etat.2020.00024
Journal volume & issue
Vol. 1, no. 6
pp. 391 – 400

Abstract

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Liquid biopsy has emerged as a minimally invasive alternative to tumor tissue analysis for the management of lung cancer patients, especially for epidermal growth factor receptor (EGFR) oncogene addicted tumor. In these patients, despite the clear benefits of tyrosine kinase inhibitors therapy, the development of acquired resistance and progressive disease is inevitable in most cases and liquid biopsy is important for molecular characterization at resistance and, being non-invasive, may be useful for disease monitoring. In this review, the authors will focus on the applications of liquid biopsy in EGFR-mutated non small cells lung cancer at diagnosis, during treatment and at progression, describing available data and possible future scenarios.

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